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     璇ラ」鐮旂┒琛ㄦ槑锛屼笌NHA鐩告瘮锛孏SC缁嗚優瀵笰CT001鏇存晱鎰熴€傞€氳繃RNA-Seq鍒嗘瀽姣旇緝锛岄娴婣EBP1鏄疉CT001鐨勬柊闈舵爣銆傝繘涓€姝ュ疄楠屽彂鐜帮紝鏁蹭綆AEBP1锛屽彲鎶戝埗GSC缁嗚優澧炴畺鍜岀缁忚兌璐ㄧ槫鐞冪殑褰㈡垚锛涚敤ACT001鎴朠I3K鎶戝埗鍓傛垨鏁蹭綆AEBP1鍩哄洜锛屾姂鍒禛SC缁嗚優AKT纾烽吀鍖栧拰澧炴畺锛岃€孉KT婵€娲诲墏鍙仮澶岮CT001娌荤枟鎴栨暡浣嶢EBP1鎶戝埗鐨勭粏鑳炲娈栥€傛澶栵紝ACT001闃绘柇浜咷SC缁嗚優涓璗GF-β婵€娲荤殑AEBP1/AKT淇″彿浼犲銆侫CT001浣滀负鍗曚竴鑽墿鎴栦笌纾烽吀閰禨HP-2鐨勬姂鍒跺墏SHP099鑱斿悎浣跨敤锛屾樉绀烘槑鏄剧殑鎶楄偪鐦ゆ椿鎬э紝鏄捐憲寤堕暱鑽风槫灏忛紶鐨勭敓瀛樻湡銆傚洜姝わ紝AEBP1鏄疉CT001娌荤枟GBM鐨勬柊鍨嬭嵂鐗╅澏鏍囷紝ACT001涓嶴HP099鑱斿悎娌荤枟鏈夋湜鏄竴绉嶆柊鐨勬不鐤楄兌璐ㄧ槫鐨勬柟娉曘€侟br />      涓婃捣浜ら€氬ぇ瀛﹀尰瀛﹂櫌闄勫睘浠佹祹鍖婚櫌鍐捣蹇犵爺绌跺憳鍜岀櫧姘哥憺涓讳换涓烘枃绔犵殑鍏卞悓閫氳浣滆€咃紝璇鹃缁勬垚鍛樹警鑹充附鍜屽瓩鍗氭枃涓烘枃绔犵殑骞跺垪绗竴浣滆€呫€傝椤圭洰寰楀埌鍥藉鑷劧鍩洪噾銆佷笂娴峰競绉戝鍩虹鐮旂┒閲嶇偣椤圭洰鍜屼笂娴峰競鏁欏楂樺嘲楂樺師瀛︾寤鸿椤圭洰鐨勬敮鎸併€侟br />  
鍙傝€冩枃鐚細
Yanli Hou*, Bowen Sun*, Wenxue Liu, Bo Yu, Qiqi Shi, Fei Luo, Yongrui Bai#, and Haizhong Feng#. Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling. Theranostics.2021; 11(2): 555-566.
鍘熸枃閾炬帴锛歨ttps://www.thno.org/v11p0555.htm

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